Sileo (dexmedetomidine) Oromucosal Gel Rx
3mL Syringe
Starting At
$35.29
Sileo (dexmedetomidine) Oromucosal Gel Rx
$35.29
In Stock
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$33.53
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Guaranteed lowest authorized price. Learn more.
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Usually ships the same weekday before 3pm CT with veterinary approval.
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Requires veterinary authorization.
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Your pet's veterinarian will provide directions for use.
What is Sileo for Dogs?
- Some of the most common noises that cause fear and anxiety disorders in dogs include thunderstorms, fireworks, traffic, construction, and loud music.
- Sileo contains the sedative Dexmedetomidine, which at a low dose to help calm dogs down, without heavy sedation, so they can keep fully functional.
- Sileo is an oral gel that absorbs through the mucous membranes in the mouth and is applied between the cheek and gum line.
- Sileo starts working in 30 to 60 min and lasts 2 to 3 hours.
Why do dogs use Sileo?
- Sileo is a prescription gel given on the gums that helps dogs that suffer from anxiety and behavioral problems caused by noises (noise aversion).
What else should I know about Sileo?
- The Sileo syringe should be discarded within 4 weeks after opening.
- Pregnant women should avoid handling Sileo.
What problems could my dog have with Sileo?
- Additional doses should be given only if your veterinarian recommends it, it has been 2 to 3 hours since the last dose, your dog is still showing signs of fear and anxiety, and your dog is not sleepy from the first dose.
- Side effects of Sileo include vomiting, diarrhea, drowsiness, low energy, slow heart rate, and decreased breathing.
What is in Sileo?
- Sileo contains the drug Dexmedetomidine.
- Dexmedetomidine works as a sedative and pain reliever.
Will I get what I see in the picture?
- Sileo is a brand name. You will receive the exact brand that you request.
Is it important for my dog to finish all of the Sileo?
- Dogs may use Sileo for different lengths of time. Please consult your veterinarian if you have any questions.
How do you use Sileo?
- Sileo absorbs through the mucous membranes in the mouth.
- Dots of the Sileo gel are applied between the cheek and gum line.
- Wear gloves when handling Sileo to protect yourself.
- It is important to make sure the dosing ring is locked in place before administering Sileo to prevent an accidental overdose.
Sileo Dosing Video:
Sileo Further Dosing Video:
Review Summary
28 total reviews
Rated 4.61 out of 5 stars
100% of respondents would recommend this to a friend
Ratings Distribution
22 5 star reviews
2 4 star reviews
3 3 star reviews
1 2 star reviews
0 1 star reviews
Most Liked Positive Review
Great product for dogs with noise induced anxiety!
We have a Lhasa who's terrified of thunder and fireworks. We have tried giving her Melatonin as well as have her wear the Thundershirt but after a while she would get accustomed to it and her anxiety would return. We gave her the amount of Sileo prescribed by her veterinarian and instead of shaking like a leaf like she normally would, she was calm and went to sleep comfortably. We've given this ahead of time when we knew a storm was coming (as well as on NYE) and given it once the storm was already over us. In both cases it worked in keeping her calm and reducing her noise induced anxiety to almost zero. We did not notice any adverse reactions to this product.
Most Liked Negative Review
Ok for sileo
I have a 13 yr old lab that any of the usual meds have had disappointing results. The fireworks were quieter this year but my neighbor had illegals. It took a second dose to get him yo sleep plus a little extra. With his size that was it.i expected better results
Reviews
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Great pet Rx service, Penny's Sileo works for her!
From UndisclosedComments about Sileo (dexmedetomidine) Oromucosal GelMy sweet dog , Penny Grace has a terrible response to thunderstorms. She is so stressed by regular daily noises, such as glasses or plates being placed in dishwasher. This medication was offered and at first I was reluctant because it was so new, but the tranquilizers, and Thundershirt was not working. Sileo has been a "miracle" for my dog. Correct timing before the storm, and combining with the diazepam tablet medication greatly reduces her reactions. It has proven to not be troublesome for Penny, by that I mean no side effects. I found the best price here and have ordered two at a time. Any medication,just like for us, has to be considered by your vet, and their knowledge and recommendation for your dog, some heart and other conditions would make Sileo, perhaps not the best choice. I have received great service from Vet Rx Direct. My last order was on a brief hold, needed a refill okay from Dr Stacey, as soon as I communicated the need to ship, storms forecasted in my region, the Sileo was shipped and received in time for Penny,!-
![Great pet Rx service, Penny's Sileo works for her!]()
Sweet Penny Grace, rescue, Paws in Prison, AR dog. Lab, and super dog mix. ❤️
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Great but pricey
From UndisclosedComments about Sileo (dexmedetomidine) Oromucosal GelIt's a great product in as far as it works really well. It does take a good 20-30 minutes to start working though and it does not last more than 2-3 hours. Most thunderstorms don't last that long but if they do, you are going to need another dose, and it is really expensive. -
I try to keep Sileo on hand during the thunder storms.
From UndisclosedComments about Sileo (dexmedetomidine) Oromucosal GelMy little dog gets very upset when there is a thunder storm or fireworks. I give her Sileo and it calms her down real good. -
I would buy this product again
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelUse this with my Yorkie during thunderstorms. Great product and VetRx are easy to work with -
For Treating Loud Noises
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelGood for 4th of July. Make sure your dog does not drink water or eat 15 minutes after application so that the medicine may dissolve by the gums and jawline. -
I would order again
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelGreat service -
A must for July 4
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelFinally, after 10 years of having my dog, we were both able to enjoy July 4. I have tried everything through the years, and nothing worked until this. An absolute must for dogs terrified of fireworks!! Thank You!! -
Def worth a try!!
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelI've used every product out there for my dog and her fear of fireworks and thunder storms. This product has hands down been the best I've used! She doesn't get drunk like on it either. She just calms down and is able to sleep through them. I highly recommend this product -
Ok for sileo
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelI have a 13 yr old lab that any of the usual meds have had disappointing results. The fireworks were quieter this year but my neighbor had illegals. It took a second dose to get him yo sleep plus a little extra. With his size that was it.i expected better results -
Mild results at best
From undisclosedComments about Sileo (dexmedetomidine) Oromucosal GelI used this for the 4th of July for my dog's fireworks anxiety. It appeared to work well for about an hour. After that he spent the next 3 hours barking and trying to hide. I will try something else next time.
Displaying Reviews 11 - 20
Q & A
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What is the shelf life of Sileo gel in an UNOPENED tube? Should it be stored in the refrigerator long term??
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The shelf life of an unopened Sileo syringe will last until the expiration date listed on the box when the product is stored at the recommended conditions. After opening, the syringe should be discarded after 4 weeks. The manufacturer states the product should be kept in controlled room temperature (68-77℉). Therefore, the medication should not be refrigerated. For further questions related to the expiration date of Sileo Oromucosal gel currently in stock, please contact customer service via email at [email protected] or by phone at 866.761.6578. Please be aware that inventory and corresponding expiration dates can change rapidly.
Verified Answer
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It says Sileo is to help with noise. My vet mentioned Sileo to me to help with my dog's anxiety when he needs to be in the car. His anxiety is caused by being in the car (even if the car isn't running), not noise from the car ride/traffic. Is Sileo likely to help for this or was I guided to a medicine that won't help??
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Sileo is FDA approved for the treatment of noise aversion in dogs. Under the direction and guidance of a veterinarian, Sileo is also used extra-label or off-label to reduce fear and anxiety during veterinary examinations. It contains the active ingredient Dexmedetomidine that works as a sedative and pain reliever. If your dog is still showing signs of anxiety 2-3 hours after administration then please speak with your veterinarian regarding additional doses and/or an alternative product.
Verified Answer
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Why does the medication need to be thrown away 4 weeks after opening the syringe??
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The manufacturer of Sileo for Dogs lists the beyond-use date as 4 weeks after the syringe is opened due to stability and sterility concerns for the medication after that time. Beyond 4 weeks, the manufacturer cannot guarantee the medication will be effective or uncontaminated by bacteria and other microbes.
Verified Answer
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I have a dog who takes phenobarbital for seizures, I need an additional medication I can give him for fireworks/storms. Can this be taken with the phenobarbital??
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According to Plumb’s Veterinary Drugs, Sileo should be used with caution in animals that have or are prone to developing seizures. The active ingredient in Sileo, Dexmedetomidine, was shown to lower the seizure threshold in animal studies. In combination, a dose reduction of both Phenobarbital and Sileo may be needed due to the potential additive effects of these medications combined. Please contact your Veterinarian to see if Sileo is safe for your dog's specific situation.
Verified Answer
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I used the correct dosage per the chart for my dog (4 dots) and administered it correctly but I saw no change in her during an event with very loud noises. Her weight is a little more than in the middle range for 4 dots and my question is, will giving her 5 dots help her better but still not make her drowsy? This is an event she participates in.?
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Would like more details on how is it administered. Thank you.?
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Please see the administration videos and document available in the More Info section on our website. If you have additional questions please give us a call.
Verified Answer
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I have a 40lb dog, which would be 4 doses/syringe. If I only use 1 dose, how long can I store the other 3 doses and how would they be stored??
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Sileo syringes are recommended to be used within two weeks of opening the syringe. Following the use of the first dose, the syringe can be stored in its original packaging at a controlled room temperature of 68-77 degrees Fahrenheit, as well as temperatures through 59-86 degrees Fahrenheit for a limited amount of time.
Verified Answer
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I purchased two tubes of silo gel for my dog the insert says it's supposed to be a clear or white Crystaline in color and both tubes or green color gel is this product so good thank you?
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The products you received are the correct color. Sileo Gel is is a teal-green translucent color. The white, crystalline substance referred to in the insert is the active ingredient, dexmedetomidine, which is dissolved in the green-teal gel for administration.
Verified Answer
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Displaying Questions 1 - 8